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Flyers are one of the easiest printing jobs and can provide that one-two punch in getting peoples' attention.
I think that it is important not to get too crazy with fonts and graphics. Too much overwhelms the eye as well as create a problem for your printer in trying to locate and use so many extra files.
Keep it simple and not use more than 3 fonts. Make sure that the graphics tie into the subject and add emphasis to what you are promoting. Avoid fonts named after cities -- they are ugly and should not be brought out for public display.
Yellow is one color that is most recognized by the human eye and easily draws people in. Avoid dark colors as they will drown out type and graphics alike and make it more challenging for people to read them.